Whole genome analysis for QTL/association enrichment
Running...
Version: Enrich S: beta v0.8
Data:
Number of blood parameters traits:
45
Number of QTL / associations found:
302
Number of chromosomes where QTL / associations are found:
29
Chi-squared (χ2) test: are blood parameters traits over-represented on some chromosomes?
Chromosomes
Total χ2
df
p-values
FDR *
Size of χ2
Chromosome Z
1336.43520
28
5.431945e-264
1.575264e-262
Chromosome 1
7473.12390
28
9e-41
2.900000e-40
Chromosome 2
919.36575
28
1.557302e-175
2.258088e-174
Chromosome 3
28.90215
28
0.4175036
5.503457e-01
Chromosome 4
248.68710
28
3.031212e-37
8.790515e-37
Chromosome 5
8.63730
28
0.9998331
9.998331e-01
Chromosome 6
90.88875
28
1.439228e-08
2.455154e-08
Chromosome 7
25.17705
28
0.6181825
7.170917e-01
Chromosome 8
50.35905
28
0.005895903
8.141961e-03
Chromosome 9
397.09755
28
7.561415e-67
7.309368e-66
Chromosome 10
8.63730
28
0.9998331
9.998331e-01
Chromosome 11
50.35905
28
0.005895903
8.141961e-03
Chromosome 12
25.17705
28
0.6181825
7.170917e-01
Chromosome 13
84.18375
28
1.564566e-07
2.520690e-07
Chromosome 14
50.35905
28
0.005895903
8.141961e-03
Chromosome 15
177.75990
28
1.018177e-23
2.271318e-23
Chromosome 16
382.94190
28
5.605837e-64
2.322418e-63
Chromosome 17
0.73980
28
0.998329325823115
9.998331e-01
Chromosome 18
25.17705
28
0.6181825
7.170917e-01
Chromosome 19
382.94190
28
5.605837e-64
2.322418e-63
Chromosome 20
90.88875
28
1.439228e-08
2.455154e-08
Chromosome 21
305.90550
28
1.647105e-48
5.970756e-48
Chromosome 22
126.65070
28
1.667432e-14
3.223702e-14
Chromosome 23
126.65070
28
1.667432e-14
3.223702e-14
Chromosome 24
382.94190
28
5.605837e-64
2.322418e-63
Chromosome 25
382.94190
28
5.605837e-64
2.322418e-63
Chromosome 26
177.75990
28
1.018177e-23
2.271318e-23
Chromosome 27
177.75990
28
1.018177e-23
2.271318e-23
Chromosome 28
8.63730
28
0.9998331
9.998331e-01
Chi-squared (χ2) test: Which of the 45 blood parameters traits are over-represented in the QTLdb
Traits
Total χ2
df
p-values
FDR *
Size of χ2
Base excess
71.66156
44
0.005264324
4.737892e-02
Blood albumin level
24.425
44
0.9926617
1.000000e+00
Blood bicarbonate level
51.34558
44
0.2079717
8.507933e-01
Blood calcium level
74.50003
44
0.002760248
3.105279e-02
Blood carbon dioxide level
48.49718
44
0.2964852
1.000000e+00
Blood cell count (total)
9.67369
44
1
1.000000e+00
Blood globulin level
8.33884
44
1
1.000000e+00
Blood hemoglobin level
46.49136
44
0.3701177
1.000000e+00
Blood pH
39.9991
44
0.6437357
1.000000e+00
Blood potassium level
67.14446
44
0.01386961
1.032899e-01
Blood total protein level
14.26611
44
0.999994
1.000000e+00
CO2 partial pressure
40.83142
44
0.6082118
1.000000e+00
Cholesterol level
31.9416
44
0.9120118
1.000000e+00
Corticosterone level
19.77885
44
0.9993928
1.000000e+00
Corticosterone response
27.67981
44
0.9740878
1.000000e+00
Creatine kinase level
16.20715
44
0.9999598
1.000000e+00
Glucagon level
63.3209
44
0.02961541
1.665867e-01
Glucose level
17.17594
44
0.9999083
1.000000e+00
Hematocrit value
24.30727
44
0.9930345
1.000000e+00
Heterophil number
21.47648
44
0.9983105
1.000000e+00
Heterophil/lymphocyte ratio
74.95573
44
0.002482261
3.105279e-02
Insulin level
25.856
44
0.9866884
1.000000e+00
Insulin to glucagon ratio
19.56616
44
0.9994716
1.000000e+00
Insulin-like growth factor II level
38.7834
44
0.6942232
1.000000e+00
Insulin-like growth factor level
17.06235
44
0.9999164
1.000000e+00
LDL cholesterol level
6.29671
44
1
1.000000e+00
Lactate level
27.42907
44
0.9762204
1.000000e+00
Lymphocyte number
27.55953
44
0.9751283
1.000000e+00
Mean blood cell volume
34.65012
44
0.8425779
1.000000e+00
Mean corpuscular hemoglobin concentration
11.08003
44
0.9999999
1.000000e+00
Monocyte number
32.9178
44
0.889812
1.000000e+00
Non-esterified fatty acid level
52.52778
44
0.1771560
7.972020e-01
O2 partial pressure
49.33336
44
0.268446
1.000000e+00
Oxygen saturation
230.05007
44
5.013051e-27
2.255873e-25
Platelet count
22.16
44
0.9975474
1.000000e+00
Plateletcrit
38.26666
44
0.7149823
1.000000e+00
Red blood cell count
32.55559
44
0.8984221
1.000000e+00
Red cell distribution width
29.35716
44
0.955887
1.000000e+00
Thyroxine level
12.48746
44
0.9999993
1.000000e+00
Triglyceride level
56.52643
44
0.09751987
4.875993e-01
Triiodothyronine level
32.92039
44
0.8897489
1.000000e+00
Triiodothyronine to thyroxine ratio
37.41944
44
0.7478702
1.000000e+00
Troponin T concentration
25.74466
44
0.9872603
1.000000e+00
VLDL cholesterol level
88.29824
44
8.454453e-05
1.902252e-03
beta 2-globulin level
66.42564
44
0.01606732
1.032899e-01
Correlations found between some of these traits for your reference
No correlation data found on these traits
Overall Test
Data
Chi'Square Test
Fisher's Exact Test
Number of chrom.:
29
χ2
=
13547.087100
Number of traits:
45
df
=
1232
Number of QTLs:
302
p-value
=
0
FOOT NOTE: * : FDR is short for "false
discovery rate", representing the expected proportion of type I errors. A type I
error is where you incorrectly reject the null hypothesis, i.e. you get a false
positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where
V = Number of Type I errors (false positives); R = Number of rejected hypotheses.
Benjamini–Hochberg procedure is a practical way to estimate FDR.
Running...
