QTLdb: entrichment tests

Release 57
(Aug 26, 2025)

Whole genome analysis for QTL/association enrichment

Running...

Version: Enrich S: beta v0.8

Search:	to limit the list of your trait choices:
	(optional) focus on chromosome with Mb windows across its length

Data:

Number of disease traits:	21
Number of QTL / associations found:	3,546
Number of chromosomes where QTL / associations are found:	30

Chi-squared (χ²) test: are disease traits over-represented on some chromosomes?

Chromosomes	Total χ²	df	p-values	FDR ^*	Size of χ²
Chromosome X	1892.17455	29	9e-41	1.687500e-40
Chromosome 1	191.13906	29	8.527407e-26	1.279111e-25
Chromosome 2	227.70258	29	1.014738e-32	1.602218e-32
Chromosome 3	2382.42333	29	9e-41	1.687500e-40
Chromosome 4	162.03747	29	1.969548e-20	2.568976e-20
Chromosome 5	69.65175	29	3.383269e-05	3.624931e-05
Chromosome 6	15545.26596	29	9e-41	1.687500e-40
Chromosome 7	184.21011	29	1.665537e-24	2.379339e-24
Chromosome 8	259.25592	29	8.102004e-39	1.350334e-38
Chromosome 9	484.10859	29	5.264083e-84	2.256036e-83
Chromosome 10	389.12895	29	1.179413e-64	4.422799e-64
Chromosome 11	131.44362	29	5.38022e-15	6.456264e-15
Chromosome 12	484.10859	29	5.264083e-84	2.256036e-83
Chromosome 13	259.25592	29	8.102004e-39	1.350334e-38
Chromosome 14	127.60608	29	2.475291e-14	2.856105e-14
Chromosome 15	46.62630	29	0.02031079	2.101116e-02
Chromosome 16	1247.64171	29	2.866632e-244	4.299948e-243
Chromosome 17	316.39293	29	4.574042e-50	1.247466e-49
Chromosome 18	172.94613	29	2.005864e-22	2.735269e-22
Chromosome 19	33.83457	29	0.2453675	2.453675e-01
Chromosome 20	1497.22545	29	2.130697e-297	6.392091e-296
Chromosome 21	121.95645	29	2.291400e-13	2.546000e-13
Chromosome 22	141.28632	29	1.021953e-16	1.277441e-16
Chromosome 23	2722.97151	29	9e-41	1.687500e-40
Chromosome 24	1031.60106	29	1.808038e-198	1.808038e-197
Chromosome 25	347.09346	29	3.413587e-56	1.024076e-55
Chromosome 26	581.29134	29	4.860869e-104	3.645652e-103
Chromosome 27	1576.53510	29	9e-41	1.687500e-40
Chromosome 28	347.09346	29	3.413587e-56	1.024076e-55
Chromosome 29	502.83450	29	7.52676e-88	4.516056e-87

Chi-squared (χ²) test: Which of the 21 disease traits are over-represented in the QTLdb

Traits	Total χ²	df	p-values	FDR ^*	Size of χ²
Bovine coronavirus susceptibility	129.14792	20	5.631331e-18	1.478224e-17
Bovine leukemia virus susceptibility	297.64409	20	2.446494e-51	1.712546e-50
Bovine respiratory disease susceptibility	272.13077	20	3.810679e-46	2.000606e-45
Bovine spongiform encephalopathy susceptibility	56.76843	20	2.225349e-05	4.248394e-05
Bovine tuberculosis susceptibility	249.55891	20	1.401914e-41	5.888039e-41
Bovine viral diarrhea virus susceptibility	189.97871	20	1.068252e-29	3.204756e-29
Cholesterol deficiency	37.96702	20	0.008938098	1.340715e-02
Cystic ovaries	50.18206	20	0.0002085668	3.649919e-04
Dwarfism	14.15383	20	0.8226115	8.226115e-01
Endometritis	29.01347	20	0.08749447	1.080814e-01
Epidermolysis bullosa	38.39998	20	0.007909986	1.277767e-02
Foot-and-mouth disease susceptibility	205.84417	20	7.827598e-33	2.739659e-32
General disease susceptibility	34.48681	20	0.02301414	3.221980e-02
Infectious bovine keratoconjunctivitis susceptibility	69.08323	20	2.569003e-07	5.394906e-07
Ketosis	976.21485	20	4.598117e-194	9.656046e-193
M. paratuberculosis susceptibility	566.21766	20	3.708462e-107	3.893885e-106
Marfan syndrome-like disease	32.07441	20	0.04251186	5.579682e-02
Metritis	22.35077	20	0.3217842	3.556562e-01
Milk fever	14.34662	20	0.8124957	8.226115e-01
Percentage decrease in body weight up to day 150 after challenge	26.36595	20	0.154063	1.797402e-01
Rabies antibody titer	78.59092	20	6.800809e-09	1.586855e-08

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data		Chi'Square Test			Fisher's Exact Test
Number of chrom.:	30	χ²	=	33476.842770
Number of traits:	21	df	=	580
Number of QTLs:	3,546	p-value	=	0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.